Ashwagandha has been a cornerstone of Ayurvedic medication for hundreds of years, identified for its potential to spice up energy, vitality, and psychological readability.
But fashionable medication remained skeptical of its advantages—till lately.
New analysis is now confirming lots of ashwagandha’s conventional makes use of. Research present that ashwagandha capsules can cut back nervousness, enhance sleep, improve athletic efficiency, and assist immune well being.
And that’s why ashwagandha has change into a go-to complement for anybody seeking to optimize their thoughts, physique, and general well-being.
On this article, you’ll uncover what ashwagandha is, the way it works, and the highest science-backed advantages of including it to your complement routine.
What Is Ashwagandha?
Ashwagandha is a root from Ayurveda, the normal Indian system of medication. It comes from the ashwagandha plant, often known as Withania somnifera, which grows in India, Africa, and the Center East.
It’s typically referred to as “the horse herb” as a result of the identify “ashwagandha” means “odor of horse,” a nod to its robust odor. Individuals used to say it gave you the energy of a horse, too—an early instance of selling hype.
The important thing factor to learn about ashwagandha is that it’s an adaptogen—a substance that helps you “adapt” to emphasize. It really works by inflicting a small, unperceivable stress within the physique, which triggers a stronger response to deal with future stressors extra successfully.
Historically, males used ashwagandha to spice up vitality, vigor, sexual well-being, and energy. In the present day, it’s a preferred complement for enhancing cognitive operate, temper, athletic efficiency, and general well being.
What Is KSM-66 Ashwagandha Extract?
Spend any time researching ashwagandha capsules, and it gained’t be lengthy till you hear point out of “KSM 66 ashwagandha extract.”
However what precisely is KSM-66, and the way does it differ from common ashwagandha?
KSM-66 ashwagandha is a patented type of ashwagandha discovered in lots of top-quality dietary supplements. It comprises 5% withanolides, the lively compounds that present most of ashwagandha’s advantages.
All ashwagandha dietary supplements comprise some withanolides, however their focus can vary from 1% to over 35%, relying on how producers develop, course of, and retailer the plant. Dietary supplements that don’t specify withanolide content material would possibly comprise too little to be efficient or an excessive amount of to be protected.
The supply of withanolides additionally issues.
KSM-66 ashwagandha makes use of solely the foundation of the ashwagandha plant, whereas some producers use the leaves to chop prices. Whereas there’s no direct proof that leaf-based dietary supplements are dangerous, most research deal with the foundation, not the leaves.
That’s why many contemplate KSM-66 the gold normal of ashwagandha extracts, particularly in relation to dietary supplements.
What Does Ashwagandha Do?
As I’ve talked about, ashwagandha’s advantages come primarily from a bunch of molecules referred to as withanolides.
There are greater than a dozen withanolides, however the two most essential are withanolide A and withaferin A. These are probably the most potent and ample in ashwagandha.
At this level, I’d normally dive into how these molecules work together with the physique—however right here’s the catch: we nonetheless don’t totally perceive how adaptogens, like ashwagandha, work within the mind.
After which there’s withaferin A—a “promiscuous” molecule.
In chemistry, promiscuity refers to molecules that work together with many various “targets,” and withaferin A is a main instance. This makes analysis tough as a result of it’s laborious to pinpoint precisely what it’s doing.
Nonetheless, scientists have made some educated guesses about how ashwagandha works.
A number one idea is that it influences the hypothalamic-pituitary-adrenal (HPA) axis—the system that controls how your physique responds to emphasize, which may clarify its wide-reaching results.
That mentioned, there’s nonetheless a lot we don’t know. Ashwagandha might have an effect on the HPA axis in a different way in numerous individuals, which could clarify why research typically present combined outcomes.
The Prime 7 Ashwagandha Advantages
Analysis exhibits that KSM-66 ashwagandha gives the next seven advantages:
- Elevated energy, energy, and endurance
- Lowered stress and nervousness
- Decrease cortisol
- Enhanced sleep high quality
- Lowered irritation and better antioxidant ranges
- Improved fertility in males
- Higher immune operate
Let’s take a look at every in additional depth.
Elevated Energy, Power, and Endurance
Research exhibits that taking ashwagandha boosts energy and energy output in weightlifters and sedentary people alike.
For instance, in a study printed within the journal Vitamins, weightlifters taking ashwagandha gained considerably extra energy than these taking a placebo.
These taking ashwagandha capsules elevated their bench press energy by 101 kilos versus 58 kilos within the placebo group, and their leg extension energy by 32 kilos in comparison with 22 kilos.
In addition they gained extra muscle, misplaced extra fats, had greater testosterone ranges, and skilled much less muscle injury.
It additionally appears to enhance cardiovascular endurance, significantly VO2 max.
Lowered Stress and Anxiousness
Research present that ashwagandha helps cut back nervousness attributable to continual stress.
In a single study, individuals with continual stress reported feeling a lot much less anxious after taking ashwagandha. One other study discovered it helped cut back stress-related overeating in overweight individuals, which helped them shed weight.
Ashwagandha additionally appears to be efficient for tackling normal nervousness, although the consequences are strongest when stress is the primary trigger.
Apparently, ashwagandha might even enhance “social functioning.”
Studies on rats present elevated social interplay, and a few human studies report “improved sociability” (willingness to take part in social actions) as a facet profit, even when stress isn’t the foundation situation.
Lowered Cortisol
Cortisol is a hormone that spikes in response to emphasize. Whereas it’s useful for growing alertness, fats burning, and lowering irritation within the quick time period, persistently elevated cortisol may cause the other—resulting in fatigue, fats achieve, illness, and dysfunction.
Studies show that taking ashwagandha capsules can cut back cortisol ranges by 15-to-28% in careworn people. In animal research, this discount has led to higher immune operate, as cortisol can suppress the immune system.
What’s spectacular right here is the magnitude of the impact.
In a world filled with exaggerated complement claims, a 15% discount in cortisol is a significant outcome, making ashwagandha one of many stronger choices for managing stress-induced cortisol spikes.
Enhanced Sleep High quality
Research shows that ashwagandha can considerably enhance sleep high quality, even for individuals with insomnia.
In a single 8-week study, 80 members cut up into 4 teams: these with out sleep points and people with insomnia, with every group additional cut up into ashwagandha or placebo teams.
The researchers gave these taking ashwagandha 600 mg every day (300 mg twice a day), after which tracked everybody’s “sleep onset latency” (how lengthy it took to go to sleep), complete sleep time, and psychological alertness upon waking at 1, 4, and eight weeks.
The outcomes have been spectacular.
These taking ashwagandha capsules, particularly these with insomnia, fell asleep sooner, slept longer, and reported higher sleep high quality and better alertness within the morning in comparison with the placebo teams.
One other 6-week study involving 150 wholesome adults with sleep disturbances reported related findings. Contributors who took 120 mg of ashwagandha extract skilled vital enhancements in sleep onset, complete sleep time, sleep effectivity, and lowered waking throughout the night time.
What’s extra, self-reported sleep high quality elevated by 72% within the ashwagandha group, in comparison with simply 29% within the placebo group, and their general high quality of life additionally improved.
Lowered Irritation and Will increase Antioxidant Ranges
Outcomes from studies on reminiscence impairment present that taking ashwagandha capsules reduces irritation within the mind and protects mind cells from oxidative injury.
This impact is linked to withaferin A and withanone, which assist restore neurons and enhance connections between them.
Ashwagandha additionally helps steadiness the degrees of essential proteins in your mind, like brain-derived neurotrophic issue (BDNF) and glial fibrillary acidic protein (GFAP), that are essential for mind well being and reminiscence.
Improved Fertility in Males
For generations, males have used ashwagandha to spice up fertility.
In the present day, research supports this traditional use, exhibiting that ashwagandha can enhance sperm high quality, regulate key fertility hormones, and defend the reproductive system from injury.
It additionally helps alleviate stress and nervousness, that are main contributors to sexual dysfunction.
As an example, a 2022 study involving 50 wholesome males confirmed that ashwagandha root extract improved general sexual operate, together with sexual need, arousal, and efficiency.
Males taking ashwagandha capsules have been additionally 89% extra possible to enhance their general sexual well being in comparison with the placebo group, with vital enhancements in areas like arousal, conduct, orgasm, and need.
Enhanced Immune Operate
Ashwagandha seems to assist immune well being, although it’s unclear if this is because of its potential to scale back stress, which may weaken your immune defenses.
In different phrases, it could not directly enhance immune operate by decreasing stress quite than instantly bettering how your immune system works.
Nonetheless, studies show taking ashwagandha capsules can enhance a number of markers of immune operate and may play a task in stopping or treating respiratory infections.
Ashwagandha’s antioxidant and anti inflammatory properties might clarify a few of its immune advantages.
As an example, research shows that taking 500-to-5,000 mg every day for 8-to-12 weeks can improve antioxidants, cut back oxidative stress markers like malondialdehyde, and enhance train restoration, lung operate, and general high quality of life.
Does Ashwagandha Enhance Testosterone?
A typical declare is that ashwagandha advantages testosterone manufacturing, boosting “T” in even probably the most virile males.
Whereas this in all probability isn’t true, there’s proof that it could possibly improve T in some situations
As an example, ashwagandha has been proven to boost testosterone ranges in males with fertility points, significantly when their infertility is related to emphasize or poor semen high quality.
This impact could also be on account of ashwagandha’s antioxidant properties, which assist defend the testicles and enhance hormone manufacturing.
The one research on ashwagandha and testosterone in in any other case wholesome males comes from analysis on new weightlifters.
On this study, ashwagandha capsules improved muscle mass and energy, and testosterone ranges elevated by round 15%.
Crucially, this boost in testosterone might have been a facet impact of gaining muscle quite than the reason for it. In any case, getting stronger and extra muscular can naturally increase testosterone in newbie weightlifters.
Sadly, there’s not sufficient proof to say whether or not ashwagandha boosts testosterone in wholesome, fertile, lively males.
Apparently, ashwagandha may improve libido, however this is probably not associated to testosterone ranges. For instance, studies on girls have proven enhancements in sexual operate with none adjustments in testosterone.
So, whereas taking ashwagandha capsules might technically improve testosterone, this impact is probably going extra related to males with fertility points or these coping with stress-induced hormonal imbalances. In wholesome males, its function could also be extra as a testicular antioxidant than a testosterone booster.
What Is the Clinically Efficient Ashwagandha Dosage?
In keeping with most research, the best dose of ashwagandha is 500-to-600 mg every day. Whereas it’s not important, taking it with a meal is mostly really useful.
What Are the Most Widespread Facet Results of Ashwagandha?
Ashwagandha is mostly protected, although may cause uncomfortable side effects on uncommon events.
These uncomfortable side effects fluctuate—some individuals report surprising advantages like improved urge for food or libido, whereas others expertise reactions like vertigo.
Likewise, many customers discover it helps with sleep, however a couple of have reported the other impact.
One potential situation entails its impression on thyroid operate. Ashwagandha increases thyroid hormones (T3 and T4), which can help individuals with subclinical hypothyroidism. Nevertheless, the impact will be unpredictable, and there’s at the least one case of extra thyrotoxicosis (extra thyroid hormones) linked to its use.
For that reason, individuals with overactive thyroids or these on thyroid treatment ought to keep away from ashwagandha.
What’s the Greatest Ashwagandha Complement?
If you wish to complement with ashwagandha, you should purchase it from a trusted supply.
That’s as a result of it’s widespread for natural dietary supplements to be underdosed (they don’t comprise as a lot of the lively elements as they are saying on the label), and a few can be contaminated with toxins like arsenic, mercury, lead, and cadmium.
If you happen to’re in search of a protected supply of ashwagandha, take a look at Legion’s KSM-66® ashwagandha root extract.
Third-party labs take a look at our KSM-66® ashwagandha for heavy metals, microbes, allergens, and different contaminants to make sure it meets strict purity requirements.
It additionally comprises 600 mg of KSM-66 ashwagandha per serving, which is the quantity proven by scientific analysis to boost cognitive operate, temper, and athletic efficiency and cut back irritation and oxidative stress.
(Or, for those who aren’t positive if Legion KSM-66® ashwagandha root extract is best for you or if one other complement would possibly higher suit your finances, circumstances, and objectives, then take the Legion Supplement Finder Quiz! In lower than a minute, it’ll let you know precisely what dietary supplements are best for you. Click here to check it out.)
FAQ #1: What are ashwagandha’s advantages for athletes?
Ashwagandha provides a spread of advantages for athletes, particularly in relation to enhancing cognition, response time, and general psychological sharpness.
One study discovered that taking 250 mg of ashwagandha twice a day improved response time, decision-making, and psychological focus in wholesome younger adults—abilities essential for athletes who must make quick, correct selections below strain.
Ashwagandha additionally helps stabilize temper and cut back stress, permitting athletes to remain calm and centered throughout competitors. Its potential to decrease cortisol can even help in restoration and enhance efficiency.
Past the psychological advantages, ashwagandha’s advantages for working out embody boosting endurance, energy, and restoration.
FAQ #2: What are the consequences of ashwagandha on hair loss?
Many individuals are inquisitive about whether or not ashwagandha will help with hair loss. Whereas there’s no stable proof exhibiting ashwagandha prevents or reverses hair loss, one case study does provide some perception.
Medical doctors from the New York Division of Inner Drugs discovered ashwagandha to be efficient in treating congenital adrenal hyperplasia, a genetic dysfunction that may result in hair loss. Whereas this is only one case research and never sufficient to attract broad conclusions, it could provide hope for these coping with this situation.
Past that, no substantial proof hyperlinks ashwagandha to improved hair well being. So, whereas it’s not a confirmed answer for hair loss, it could possibly be price contemplating for those who’re coping with particular points like congenital adrenal hyperplasia.
FAQ #3: How lengthy does it take for ashwagandha to work?
Most studies show that common ashwagandha supplementation improves bodily and emotional well-being inside 4-to-12 weeks. That mentioned, the precise timeline varies from individual to individual.
Scientific References +
- Law, Yu Li Lydia, et al. “Effects of Two and Five Days of Creatine Loading on Muscular Strength and Anaerobic Power in Trained Athletes.” Journal of Strength and Conditioning Research, vol. 23, no. 3, May 2009, pp. 906–914, https://doi.org/10.1519/jsc.0b013e3181a06c59. Accessed 9 Apr. 2021.
- Bonilla, Diego A., et al. “Effects of Ashwagandha (Withania Somnifera) on Physical Performance: Systematic Review and Bayesian Meta-Analysis.” Journal of Functional Morphology and Kinesiology, vol. 6, no. 1, 11 Feb. 2021, p. 20, https://doi.org/10.3390/jfmk6010020.
- Bonilla, Diego A., et al. “Effects of Ashwagandha (Withania Somnifera) on Physical Performance: Systematic Review and Bayesian Meta-Analysis.” Journal of Functional Morphology and Kinesiology, vol. 6, no. 1, 11 Feb. 2021, p. 20, https://doi.org/10.3390/jfmk6010020.
- Wankhede, Sachin, et al. “Examining the Effect of Withania Somnifera Supplementation on Muscle Strength and Recovery: A Randomized Controlled Trial.” Journal of the International Society of Sports Nutrition, vol. 12, no. 1, 2015, p. 43, www.ncbi.nlm.nih.gov/pubmed/26609282, https://doi.org/10.1186/s12970-015-0104-9.
- Pérez-Gómez, Jorge, et al. “Effects of Ashwagandha (Withania Somnifera) on VO2max: A Systematic Review and Meta-Analysis.” Nutrients, vol. 12, no. 4, 17 Apr. 2020, p. 1119, https://doi.org/10.3390/nu12041119.
- Shenoy, Shweta, et al. “Effects of Eight-Week Supplementation of Ashwagandha on Cardiorespiratory Endurance in Elite Indian Cyclists.” Journal of Ayurveda and Integrative Medicine, vol. 3, no. 4, 2012, pp. 209–14, www.ncbi.nlm.nih.gov/pubmed/23326093, https://doi.org/10.4103/0975-9476.104444. Accessed 30 Sept. 2019.
- Js, Sandhu, et al. “Effects of Withania Somnifera (Ashwagandha) and Terminalia Arjuna (Arjuna) on Physical Performance and Cardiorespiratory Endurance in Healthy Young Adults.” International Journal of Ayurveda Research, 1 July 2010, pubmed.ncbi.nlm.nih.gov/21170205/.
- K, Chandrasekhar, et al. “A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults.” Indian Journal of Psychological Medicine, 1 July 2012, pubmed.ncbi.nlm.nih.gov/23439798/.
- Choudhary, Dnyanraj, et al. “Body Weight Management in Adults under Chronic Stress through Treatment with Ashwagandha Root Extract.” Journal of Evidence-Based Complementary & Alternative Medicine, vol. 22, no. 1, 1 Jan. 2017, pp. 96–106, www.ncbi.nlm.nih.gov/pmc/articles/PMC5871210/, https://doi.org/10.1177/2156587216641830.
- Pratte, Morgan A., et al. “An Alternative Treatment for Anxiety: A Systematic Review of Human Trial Results Reported for the Ayurvedic Herb Ashwagandha (Withania Somnifera).” The Journal of Alternative and Complementary Medicine, vol. 20, no. 12, Dec. 2014, pp. 901–908, www.ncbi.nlm.nih.gov/pmc/articles/PMC4270108/, https://doi.org/10.1089/acm.2014.0177.
- Cooley, Kieran, et al. “Naturopathic Care for Anxiety: A Randomized Controlled Trial ISRCTN78958974.” PLoS ONE, vol. 4, no. 8, 31 Aug. 2009, p. e6628, journals.plos.org/plosone/article?id=10.1371/journal.pone.0006628, https://doi.org/10.1371/journal.pone.0006628.
- Andrade, C., et al. “A Double-Blind, Placebo-Controlled Evaluation of the Anxiolytic Efficacy Ff an Ethanolic Extract of Withania Somnifera.” Indian Journal of Psychiatry, vol. 42, no. 3, 1 July 2000, pp. 295–301, pubmed.ncbi.nlm.nih.gov/21407960/.
- Biswal, Biswa Mohan, et al. “Effect of Withania Somnifera (Ashwagandha) on the Development of Chemotherapy-Induced Fatigue and Quality of Life in Breast Cancer Patients.” Integrative Cancer Therapies, vol. 12, no. 4, 2013, pp. 312–22, www.ncbi.nlm.nih.gov/pubmed/23142798, https://doi.org/10.1177/1534735412464551.
- Chandrasekhar, K, et al. “A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults.” Indian Journal of Psychological Medicine, vol. 34, no. 3, 2012, pp. 255–62, www.ncbi.nlm.nih.gov/pubmed/23439798, https://doi.org/10.4103/0253-7176.106022.
- Mahdi, Abbas Ali, et al. “Withania SomniferaImproves Semen Quality in Stress-Related Male Fertility.” Evidence-Based Complementary and Alternative Medicine, vol. 2011, 2011, pp. 1–9, https://doi.org/10.1093/ecam/nep138. Accessed 28 Aug. 2020.
- Khan, Beenish, et al. “Augmentation and Proliferation of T Lymphocytes and Th-1 Cytokines by Withania Somnifera in Stressed Mice.” International Immunopharmacology, vol. 6, no. 9, 1 Sept. 2006, pp. 1394–1403, https://doi.org/10.1016/j.intimp.2006.04.001. Accessed 6 Oct. 2023.
- Kour, Kiranjeet, et al. “Restoration of Stress-Induced Altered T Cell Function and Corresponding Cytokines Patterns by Withanolide A.” International Immunopharmacology, vol. 9, no. 10, Sept. 2009, pp. 1137–1144, https://doi.org/10.1016/j.intimp.2009.05.011. Accessed 29 Nov. 2020.
- D’cruz, Migita, and Chittaranjan Andrade. “Potential Clinical Applications of Ashwagandha (Withania Somnifera) in Medicine and Neuropsychiatry.” Expert Review of Clinical Pharmacology, 4 Sept. 2022, https://doi.org/10.1080/17512433.2022.2121699. Accessed 7 Sept. 2022.
- Cheah, Kae Ling, et al. “Effect of Ashwagandha (Withania Somnifera) Extract on Sleep: A Systematic Review and Meta-Analysis.” PLOS ONE, vol. 16, no. 9, 24 Sept. 2021, p. e0257843, https://doi.org/10.1371/journal.pone.0257843.
- Langade, Deepak, et al. “Clinical Evaluation of the Pharmacological Impact of Ashwagandha Root Extract on Sleep in Healthy Volunteers and Insomnia Patients: A Double-Blind, Randomized, Parallel-Group, Placebo-Controlled Study.” Journal of Ethnopharmacology, vol. 264, Jan. 2021, p. 113276, https://doi.org/10.1016/j.jep.2020.113276.
- Deshpande, Abhijit, et al. “A Randomized, Double Blind, Placebo Controlled Study to Evaluate the Effects of Ashwagandha (Withania Somnifera) Extract on Sleep Quality in Healthy Adults.” Sleep Medicine, vol. 72, Mar. 2020, https://doi.org/10.1016/j.sleep.2020.03.012.
- D’cruz, Migita, and Chittaranjan Andrade. “Potential Clinical Applications of Ashwagandha (Withania Somnifera) in Medicine and Neuropsychiatry.” Expert Review of Clinical Pharmacology, 4 Sept. 2022, https://doi.org/10.1080/17512433.2022.2121699.
- Konar, Arpita, et al. “Protective Role of Ashwagandha Leaf Extract and Its Component Withanone on Scopolamine-Induced Changes in the Brain and Brain-Derived Cells.” PloS One, vol. 6, no. 11, 2011, p. e27265, pubmed.ncbi.nlm.nih.gov/22096544/, https://doi.org/10.1371/journal.pone.0027265. Accessed 19 Aug. 2020.
- Mahdi, Abbas Ali, et al. “Withania SomniferaImproves Semen Quality in Stress-Related Male Fertility.” Evidence-Based Complementary and Alternative Medicine, vol. 2011, 2011, pp. 1–9, https://doi.org/10.1093/ecam/nep138.
- Ambiye, Vijay R., et al. “Clinical Evaluation of the Spermatogenic Activity of the Root Extract of Ashwagandha (Withania Somnifera) in Oligospermic Males: A Pilot Study.” Evidence-Based Complementary and Alternative Medicine, vol. 2013, no. 1, 2013, pp. 1–6, downloads.hindawi.com/journals/ecam/2013/571420.pdf, https://doi.org/10.1155/2013/571420.
- Kumar, Arun, et al. “Phytoremedial Effect of Withania Somnifera against Arsenic-Induced Testicular Toxicity in Charles Foster Rats.” Avicenna Journal of Phytomedicine, vol. 5, no. 4, 2015, pp. 355–64, www.ncbi.nlm.nih.gov/pmc/articles/PMC4587609/. Accessed 25 Sept. 2024.
- Gupta, Ashish, et al. “Efficacy of Withania Somnifera on Seminal Plasma Metabolites of Infertile Males: A Proton NMR Study at 800MHz.” Journal of Ethnopharmacology, vol. 149, no. 1, Aug. 2013, pp. 208–214, https://doi.org/10.1016/j.jep.2013.06.024. Accessed 21 June 2020.
- Nasimi Doost Azgomi, Ramin, et al. “Effects of Withania Somnifera on Reproductive System: A Systematic Review of the Available Evidence.” BioMed Research International, vol. 2018, no. 1, 24 Jan. 2018, www.ncbi.nlm.nih.gov/pmc/articles/PMC5833251/, https://doi.org/10.1155/2018/4076430.
- Chauhan, Sanjaya, et al. “Effect of Standardized Root Extract of Ashwagandha (Withania Somnifera) on Well‐Being and Sexual Performance in Adult Males: A Randomized Controlled Trial.” Health Science Reports, vol. 5, no. 4, July 2022, https://doi.org/10.1002/hsr2.741.
- Adam, Emma K., et al. “Diurnal Cortisol Slopes and Mental and Physical Health Outcomes: A Systematic Review and Meta-Analysis.” Psychoneuroendocrinology, vol. 83, no. 83, Sept. 2017, pp. 25–41, https://doi.org/10.1016/j.psyneuen.2017.05.018.
- Tharakan, Ajit, et al. “Immunomodulatory Effect of Withania Somnifera (Ashwagandha) Extract—a Randomized, Double-Blind, Placebo Controlled Trial with an Open Label Extension on Healthy Participants.” Journal of Clinical Medicine, vol. 10, no. 16, 18 Aug. 2021, p. 3644, https://doi.org/10.3390/jcm10163644.
- Mikolai, Jeremy, et al. “In Vivo Effects of Ashwagandha (Withania Somnifera) Extract on the Activation of Lymphocytes.” Journal of Alternative and Complementary Medicine (New York, N.Y.), vol. 15, no. 4, 2009, pp. 423–30, www.ncbi.nlm.nih.gov/pubmed/19388865, https://doi.org/10.1089/acm.2008.0215. Accessed 10 Apr. 2020.
- Chopra, Arvind, et al. “Withania Somnifera as a Safer Option to Hydroxychloroquine in the Chemoprophylaxis of COVID-19: Results of Interim Analysis.” Complementary Therapies in Medicine, vol. 62, 1 Nov. 2021, p. 102768, www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8372474/, https://doi.org/10.1016/j.ctim.2021.102768. Accessed 4 Nov. 2021.
- Tiwari, Shashank, et al. “A Double-Blind, Randomized, Placebo-Controlled Trial on the Effect of Ashwagandha (Withania Somnifera Dunal.) Root Extract in Improving Cardiorespiratory Endurance and Recovery in Healthy Athletic Adults.” Journal of Ethnopharmacology, vol. 272, Feb. 2021, p. 113929, https://doi.org/10.1016/j.jep.2021.113929.
- Shukla, Kamla Kant, et al. “Withania Somnifera Improves Semen Quality by Combating Oxidative Stress and Cell Death and Improving Essential Metal Concentrations.” Reproductive BioMedicine Online, vol. 22, no. 5, May 2011, pp. 421–427, https://doi.org/10.1016/j.rbmo.2011.01.010. Accessed 21 June 2020.
- Singh, Priyam, et al. “Withania Somnifera (L.) Dunal as Add-on Therapy for COPD Patients: A Randomized, Placebo-Controlled, Double-Blind Study.” Frontiers in Pharmacology, vol. 13, 16 June 2022, https://doi.org/10.3389/fphar.2022.901710. Accessed 6 July 2022.
- Shariat, Ardalan, et al. “Intensive Resistance Exercise and Circadian Salivary Testosterone Concentrations among Young Male Recreational Lifters.” Journal of Strength and Conditioning Research, vol. 29, no. 1, Jan. 2015, pp. 151–158, https://doi.org/10.1519/jsc.0000000000000632. Accessed 4 May 2021.
- Dongre, Swati, et al. “Efficacy and Safety of Ashwagandha (Withania Somnifera) Root Extract in Improving Sexual Function in Women: A Pilot Study.” BioMed Research International, vol. 2015, 2015, pp. 1–9, https://doi.org/10.1155/2015/284154.
- Aa, Raut, et al. “Exploratory Study to Evaluate Tolerability, Safety, and Activity of Ashwagandha (Withania Somnifera) in Healthy Volunteers.” Journal of Ayurveda and Integrative Medicine, 1 July 2012, pubmed.ncbi.nlm.nih.gov/23125505/.
- Panda, Sunanda, and Anand Kar. “Changes in Thyroid Hormone Concentrations after Administration of Ashwagandha Root Extract to Adult Male Mice.” Journal of Pharmacy and Pharmacology, vol. 50, no. 9, Sept. 1998, pp. 1065–1068, https://doi.org/10.1111/j.2042-7158.1998.tb06923.x. Accessed 12 June 2020.
- Sharma, Ashok Kumar, et al. “Efficacy and Safety of Ashwagandha Root Extract in Subclinical Hypothyroid Patients: A Double-Blind, Randomized Placebo-Controlled Trial.” Journal of Alternative and Complementary Medicine (New York, N.Y.), vol. 24, no. 3, 2018, pp. 243–248, www.ncbi.nlm.nih.gov/pubmed/28829155, https://doi.org/10.1089/acm.2017.0183.
- van der Hooft, C. S., et al. “[Thyrotoxicosis Following the Use of Ashwagandha].” Nederlands Tijdschrift Voor Geneeskunde, vol. 149, no. 47, 19 Nov. 2005, pp. 2637–2638, pubmed.ncbi.nlm.nih.gov/16355578/.
- Abdulla, Naseem Mohammed, et al. “Heavy Metal Content of Herbal Health Supplement Products in Dubai – UAE: A Cross-Sectional Study.” BMC Complementary and Alternative Medicine, vol. 19, no. 1, 21 Oct. 2019, https://doi.org/10.1186/s12906-019-2693-3. Accessed 28 Mar. 2021.
- Sakharkar, Prashant. “Lead Poisoning due to Herbal Medications.” Indian Journal of Clinical Biochemistry, vol. 32, no. 4, 22 July 2017, pp. 500–501, https://doi.org/10.1007/s12291-017-0678-x. Accessed 31 Aug. 2021.
- Pingali, Usharani, et al. “Effect of Standardized Aqueous Extract of Withania Somniferaon Tests of Cognitive and Psychomotor Performance in Healthy Human Participants.” Pharmacognosy Research, vol. 6, no. 1, 2014, p. 12, https://doi.org/10.4103/0974-8490.122912.
- Chengappa, K. N. Roy, et al. “Randomized Placebo-Controlled Adjunctive Study of an Extract OfWithania Somniferafor Cognitive Dysfunction in Bipolar Disorder.” The Journal of Clinical Psychiatry, vol. 74, no. 11, 15 Nov. 2013, pp. 1076–1083, https://doi.org/10.4088/jcp.13m08413. Accessed 4 May 2020.
- Kalani, A., et al. “Ashwagandha Root in the Treatment of Non-Classical Adrenal Hyperplasia.” Case Reports, vol. 2012, no. sep14 1, 17 Sept. 2012, pp. bcr2012006989–bcr2012006989, https://doi.org/10.1136/bcr-2012-006989.
- Akhgarjand, Camellia, et al. “Does Ashwagandha Supplementation Have a Beneficial Effect on the Management of Anxiety and Stress? A Systematic Review and Meta‐Analysis of Randomized Controlled Trials.” Phytotherapy Research, vol. 36, no. 11, 25 Aug. 2022, https://doi.org/10.1002/ptr.7598.
