Stigma in direction of people with psychological well being circumstances resembling melancholy is properly documented (Wooden et al., 2014) and extremely frequent (see Pattie’s Mental Elf blog on the prevalence of self-stigma in depression). Nevertheless, the nature and route of the connection between stigma and melancholy has been comparatively unexplored regardless of it doubtlessly impacting approaches to therapy.
Merely put, stigma refers back to the damaging appraisal of an individual or group of individuals based mostly on a attribute or a part of their identification that’s frowned upon by mainstream society. Complicating issues, there are additionally several types of stigma, together with:
- Anticipated stigma (i.e., one’s expectation of how others will deal with them based mostly upon the identification in query)
- Enacted stigma (i.e., experiencing discrimination based mostly upon the identification or trait in query)
- Internalised or self-stigma (i.e., how one involves see oneself via the angle of others; Fox et al., 2018).
Moreover, stigmatised identities could also be seen, resembling ethnicity, or concealable, resembling psychological well being circumstances (Quinn et al., 2020). That mentioned, some psychological well being circumstances resembling body-focused repetitive behaviors (BFRBs) even have seen parts. For instance, these with BFRBs usually have evident hair-loss or pores and skin lesions (Mathew et al., 2021).
To higher perceive the connection between anticipated and internalised stigma and melancholy, O’Donnell and Foran (2024) undertook a scientific evaluate to:
- Set up whether or not anticipated and/or internalised stigma may predict ranges of melancholy
- Assess the standard of proof for a causal relationship between stigma and melancholy.

Self-stigma in individuals with melancholy is extremely frequent worldwide. Exploring whether or not these with stigmatised identities are extra liable to creating melancholy is crucial to creating preventative approaches to therapy.
Strategies
Following PRISMA pointers, the authors searched 4 on-line databases (together with a gray literature database) to determine research that:
- Collected quantitative knowledge
- Utilised legitimate and dependable stigma and melancholy measures
- Concerned individuals aged 18+ with a stigmatised identification aside from melancholy
- Included melancholy as an consequence measure
- Had been accessible in English
The authors centered on research with stigma as a predictor and melancholy as an consequence. Their curiosity was on the direct hyperlink between stigma and melancholy, not mediating results. Consequently, they excluded research that solely reported correlational analyses or confirmed a mediation diagram as a substitute of a regression desk.
The preliminary search resulted in 2000+ attainable research, and screening proceeded in levels. The researchers piloted the primary 100 outcomes with two unbiased screeners, after which every researcher independently screened all titles and abstracts, resolving discrepancies via dialogue. They utilized the Nationwide Institutes of Well being (NIH) high quality evaluation device for observational cohort and cross-sectional research, independently score research as “good,” “passable,” or “poor” and resolving inconsistencies via dialogue.
Outcomes
Research traits
Eighty-three research have been included within the systematic evaluate. Nearly all of research have been cross-sectional (n = 73) with the second commonest sort of research being longitudinal (n = 10). Throughout the research, there was a complete of 34,705 individuals. Most research included within the evaluate have been carried out in the USA (n = 39), with some illustration from Asia (n = 22), Africa (n = 9), and Europe (n = 6).
5 of the research centered completely on anticipated stigma. Sixty-one research measured internalised stigma, with an additional 9 research measuring this assemble below ‘self-stigma’. Eight of the included research measured each anticipated and internalised stigma.
The 83 research analysed 21 totally different stigmatised identities, which the authors organised below the next 5 subcategories:
- Sexual and gender minorities
- HIV/AIDS
- Sickness or disability-related (non-HIV)
- Weight
- Different
Essential findings
Sixty research confirmed direct proof for a optimistic hyperlink between internalised stigma and/or anticipated stigma and melancholy. One other 13 confirmed proof for the optimistic hyperlink with some {qualifications} (i.e., didn’t present a big relationship when different variables have been thought-about), 9 research contradicted the expected hyperlink, and one research discovered that internalized stigma predicted decrease melancholy. In complete, 12% of research didn’t assist the expected hyperlink.
Outcomes by stigmatised identification class
- 33.7% of the research centered on the hyperlink between stigma associated to sexual or gender minority standing and melancholy, with roughly half (53.6%) supporting a optimistic relationship between anticipated and/or internalised stigma with ranges of/probability of melancholy.
- 32.5% of the research examined the hyperlink between HIV/AIDS stigma and melancholy. 23 of the 27 research (85.2%) discovered a big optimistic hyperlink between anticipated and/or internalised stigma and melancholy.
- 9.6% of the research centered on the hyperlink between weight stigma and melancholy. The entire research on this class discovered a big optimistic hyperlink between anticipated and/or internalised stigma and melancholy.
- 15.7% of the research explored the connection between sickness or disability-related stigma and melancholy, with essentially the most generally studied diseases being COVID-19 and most cancers. Given the vary of circumstances, this class lacked ample cohesion for significant quantitative evaluation and comparability.
- Just like the above, though 8.9% of included research have been categorised as “different”, there was not sufficient similarity amongst them to attract conclusions.
Outcomes by research design
Of the 73 cross-sectional research included, the bulk (n = 56; 76.7%) supported a vital optimistic relationship between internalised and/or anticipated stigma and melancholy.
Compared, of the ten longitudinal research reviewed, solely 4 (40%) discovered a optimistic impact of internalised stigma on elevated depressive signs over time.

Of the 83 research included on this systematic evaluate, 60 discovered a direct optimistic hyperlink between anticipated and/or internalized stigma and signs of melancholy.
Conclusions
This systematic evaluate by O’Donnell and Foran (2024) concluded that anticipated and/or internalised stigma is a predictor of melancholy. Proof throughout samples confirmed internalised and/or anticipated stigma to be considerably and positively linked to ranges of melancholy, unbiased of things resembling age, gender identification, training, sexual orientation, and enacted stigma, though the energy of the connection various by sort of stigmatised identification. Provided that outcomes various significantly by research design, with cross-sectional research demonstrating a extra constant relationship than longitudinal research, the authors recommend additional examination of the influence of stigma over time.

Whereas cross-sectional research broadly assist stigma as a predictor of melancholy, longitudinal research present blended outcomes, highlighting the necessity for additional analysis on the connection between stigma and melancholy.
Strengths and limitations
Strengths
- Prior analysis has centered on internalised and enacted stigma in direction of individuals with melancholy. This evaluate makes a new contribution by highlighting how pre-existing stigma can influence one’s melancholy, furthering our understanding of how marginalised populations expertise this psychological well being situation in distinctive methods.
- The methodological strengths of this text embody the authors’ adherence to the NIH high quality evaluation device for commentary cohort and cross-sectional research, which was used to conduct a top quality evaluation of every included research. Research have been of “good” or “honest” high quality, indicating the relative reliability of the findings.
- Nearly all of research included within the evaluate used well-validated measures of internalised stigma, anticipated stigma, and melancholy, which have been used throughout all kinds of contexts and constantly present dependable outcomes measuring the meant assemble.
Limitations
- Methodological limitations embody the use of a scientific evaluate moderately than a meta-analysis, which might enable for a extra exact estimate of impact sizes and supply extra quantitative analysis and synthesis of the information. It is usually not solely clear why the authors determined towards a meta-analysis.
- The authors didn’t embody kappa values to point inter-rater reliability between the 2 screeners. It’s due to this fact unknown if there was good reliability between the screeners, which might enhance confidence within the findings.
- The authors didn’t elaborate on how they retrieved the recognized data, and 19 studies have been unavailable because of the authors’ requests for entry not being returned; nevertheless, they don’t make it clear how they went about attempting to acquire these studies. These studies may doubtlessly maintain necessary info in relation to the systematic evaluate, which may influence its validity and reliability.
- The majority of research included within the evaluate have been cross-sectional, that means that the authors can not make claims about how stigma impacts melancholy over time. Nevertheless, understanding the connection over time is crucial to establishing a causal relationship, which may subsequently assist us to know what must be focused in interventions.
- Findings from longitudinal research have been totally different from the outcomes of the cross-sectional research included, indicating a weaker hyperlink between stigma and melancholy. Nevertheless, provided that the variety of longitudinal research included was a lot decrease than the variety of cross-sectional research, it’s troublesome to attract conclusions in regards to the significance of this distinction. Additional analysis would profit from a extra balanced pattern.

Whereas the evaluate utilised well-validated measures, limitations embody an absence of longitudinal research, and a lacking rationalization as to why a meta-analysis wasn’t undertaken.
Implications for follow
The outcomes of this evaluate are necessary within the context of psychological well being circumstances past main depressive dysfunction. As reported by Thornicroft et al. (2016) of their Lancet Fee, psychological well being circumstances convey a double jeopardy to those that expertise the signs of their dysfunction and are topic to stigma, with the latter usually reported as feeling worse than the previous. Many therapeutic approaches nonetheless concentrate on the first signs of the dysfunction with out contemplating the influence of continual stigma and disgrace. That is significantly the case for lesser-known problems, the place lack of knowledge and understanding drive greater ranges of stigma.
A working example is body-focused repetitive behaviors (BFRBs) resembling trichotillomania (hair pulling) and dermatillomania, or excoriation dysfunction (skin-picking). These problems are related to vital stigma and depressive signs (Mathew et al., 2021), however are so stigmatized that many individuals with BFRBs who strategy well being professionals for assist discover that the ‘specialists’ know little to nothing about their situation (Tucker et al., 2011; Woods et al., 2006).
Moreover, whereas psychological well being circumstances are sometimes thought-about a concealable stigma, it might be that folks with BFRBs expertise self-stigma in ways in which align extra with those that expertise seen stigmas resembling weight stigma. Self-stigma can delay treatment-seeking, and people with seen stigmas might have the next probability of experiencing internalised and anticipated stigma, resulting in continual disgrace, which can then result in melancholy. These insights can inform destigmatisation efforts for clinicians and researchers to enhance scientific outcomes for individuals with BFRBs and different psychological well being circumstances which are extra seen.
For clinicians, you will need to:
- Handle stigma on the outset of therapy. Self-stigma can deter treatment-seeking, in addition to intrude with therapy adherence (Kamaradova et al., 2016). Due to this fact, you will need to ask purchasers throughout evaluation about facets of their identification that really feel stigmatised as a way to proactively determine and discover methods of addressing this potential barrier.
- Construct purchasers’ consciousness of the psychological results related to holding a stigmatised identification, alongside figuring out components which will defend towards these results.
For researchers, you will need to:
- Discover the connection between internalised and anticipated stigma in under-researched areas like BFRBs. For BRFBs, this analysis may embody excoriation dysfunction and trichotillomania as the end result measures.
- Utilise each quantitative and qualitative strategies to discover the improvement, upkeep and influence of self-stigma in people with BFRBs.
- Develop destigmatisation interventions tailor-made to these with seen stigmas resembling BFRBs.

Insights from this evaluate can inform destigmatisation efforts to enhance therapy outcomes for individuals with different types of seen stigma resembling body-focused repetitive behaviors (BFRBs).
Assertion of pursuits
None.
Hyperlinks
Main paper
O’Donnell, A. T., & Foran, A.-M. (2024). The link between anticipated and internalized stigma and depression: A systematic review. Social Science & Medication, 349, 116869–116869.
Different references
Fox, A. B., Earnshaw, V. A., Taverna, E. C., & Vogt, D. (2018). Conceptualizing and measuring mental illness stigma: The mental illness stigma framework and critical review of measures. Stigma and Well being, 3(4), 348–376.
Gonsalves, P. (2023). Self-stigma for people with depression: systematic review presents global prevalence data, risk factors and protective factors. The Psychological Elf.
Kamaradova, D., Latalova, Ok., Prasko, J., Kubinek, R., Vrbova, Ok., Mainerova, B., … & Tichackova, A. (2016). Connection between self-stigma, adherence to treatment, and discontinuation of medication. Affected person Desire and Adherence, 1289-1298.
Mathew, A. S., Harvey, A. M., & Lee, H.-J. (2021). Development of the social concerns in individuals with body-focused repetitive behaviors (SCIB) scale. Journal of Psychiatric Analysis, 135, 218–229.
Quinn, D. M., Camacho, G., Pan-Weisz, B., & Williams, M. Ok. (2019). Visible and concealable stigmatized identities and mental health: Experiences of racial discrimination and anticipated stigma. Stigma and Well being.
Thornicroft, G., Mehta, N., Clement, S., Evans-Lacko, S., Doherty, M., Rose, D., … & Henderson, C. (2016). Evidence for effective interventions to reduce mental-health-related stigma and discrimination. The Lancet, 387(10023), 1123-1132.
Tucker, B. T., Woods, D. W., Flessner, C. A., Franklin, S. A., & Franklin, M. E. (2011). The Skin Picking Impact Project: phenomenology, interference, and treatment utilization of pathological skin picking in a population-based sample. Journal of Nervousness Problems, 25(1), 88-95.
Wooden, L., Birtel, M., Alsawy, S., Pyle, M., & Morrison, A. (2014). Public perceptions of stigma towards people with schizophrenia, depression, and anxiety. Psychiatry Analysis, 220(1-2), 604–608.
Woods, D. W., Flessner, C. A., Franklin, M. E., Keuthen, N. J., Goodwin, R. D., Stein, D. J., & Walther, M. R. (2006). The Trichotillomania Impact Project (TIP): exploring phenomenology, functional impairment, and treatment utilization. Journal of Scientific Psychiatry, 67(12), 1877.