On the planet of sports activities dietary supplements, there’s a long-standing debate round creatine HCL vs monohydrate.
Each contenders, HCL creatine and creatine monohydrate, have their loyalists, every swearing by the advantages of their chosen sort.
However in research evaluating creatine monohydrate vs HCL, how do a lot of these creatine differ, what are their execs and cons, and which comes out on prime?
The brief reply: For most individuals, creatine monohydrate is the higher selection. It’s better-researched, simply as efficient, and cheaper.
That mentioned, creatine HCL has distinctive properties that would make it a worthwhile various in sure conditions.
On this article, you’ll uncover the important thing variations between creatine HCL and monohydrate, weigh their execs and cons, and discover ways to select the most suitable choice to your objectives.
Key Takeaways
- Regardless of some advertising claims, analysis evaluating creatine HCL vs. monohydrate exhibits no clear benefit for HCL, making monohydrate the only option for most individuals.
- Whereas creatine HCL dissolves extra simply and should scale back bloating, it doesn’t seem to supply higher efficiency advantages than monohydrate.
- Each creatine HCL and monohydrate enhance muscle progress and power, however monohydrate is considerably cheaper for a similar outcomes.
- To reduce potential unwanted effects, comparable to bloating, skip the loading part and take 3-to-5 grams of monohydrate each day.
What Is Creatine?
Creatine is a pure compound comprising the amino acids L-arginine, glycine, and methionine.
Your physique produces creatine naturally, however it will probably additionally take in and retailer creatine from meals like meat, eggs, and fish.
Creatine accelerates the method that produces adenosine triphosphate (ATP), our cells’ major vitality supply.
Taking creatine dietary supplements tremendously increases your physique’s creatine shops, resulting in increased muscle progress, improved power and energy, better anaerobic capability, reduced fatigue, less muscle harm and soreness after train, modified gene expression regarding hypertrophy, and greater muscle retention after grueling exercises.
Creatine HCL vs. Monohydrate: Variations
Creatine monohydrate is creatine sure to 1 molecule of water (“mono” that means one and “hydrate” referring to water).
It’s essentially the most well-studied sort of creatine out there, and research repeatedly exhibits that creatine monohydrate dietary supplements are secure and enhance your athletic efficiency as a lot or greater than different types of creatine.
Through the years, producers have modified creatine in varied methods within the hopes of constructing a sort of creatine that’s more practical than monohydrate.
Creatine hydrochloride (HCL) is one such sort.
HCL creatine is chemically just like monohydrate, solely the creatine molecules bind to hydrochloric acid fairly than water.
This distinction offers creatine HCL two potential benefits over monohydrate:
- Improved solubility: HCL creatine is extra “soluble” in water (it dissolves extra simply) than monohydrate.
- Enhanced absorption: HCL creatine strikes by means of the intestine wall extra effectively than monohydrate, optimizing the quantity your physique makes use of.
Some consider these potential advantages imply you want much less creatine HCL to fill muscle cells, resulting in much less creatine excretion and abdomen discomfort.
Creatine HCL vs. Monohydrate: The Proof
Three studies support the theoretical advantages of creatine HCL.
Nonetheless, none concerned human members—scientists studied HCL and monohydrate solubility utilizing lab tools and assessed absorption utilizing human cells, pig pores and skin, and rat brains.
Given the variations in how varied species store and course of creatine, it’s unsure if these findings would translate to dwelling people. Even when they did, creatine HCL’s advantages won’t be as important as anticipated.
That’s as a result of the few research that pit creatine monohydrate vs. HCL present they’re equally efficient.
In a single study revealed within the journal Meals and Vitamin Sciences, researchers had weightlifters take creatine monohydrate or creatine HCL each day for 4 weeks whereas following a power coaching program.
The outcomes confirmed that all the weightlifters gained comparable power on the bench and leg press, however those that took HCL appeared to lose extra fats and acquire extra “fat-free mass” (a proxy for muscle).
Whereas this would possibly appear to be a victory for HCL, two factors warrant warning.
First, the researchers decided the weightlifters’ physique fats share utilizing skinfold calipers, a technique recognized for its inaccuracy. Therefore, errors throughout measuring may simply have brought about the adjustments in physique fats share.
And second, the examine famous that solely these taking HCL noticed a big improve in fat-free mass though the monohydrate group noticed a bigger improve (3.5 kilos vs. 3.7 kilos), a discrepancy the authors failed to elucidate.
In a subsequent study by the identical analysis workforce, athletes taking HCL and monohydrate noticed comparable will increase in lean physique mass (one other proxy for muscle) and power, however solely these taking HCL noticed a lower in fats.
Once more, the scientists used skinfold calipers to find out these adjustments, which makes it troublesome to attract agency conclusions from their findings.
Within the final study to match creatine monohydrate vs. HCL, researchers discovered that each HCL and monohydrate failed to enhance athletic efficiency and anabolic (“muscle-building”) hormone ranges in younger males after one week.
These findings are unsurprising contemplating the time creatine takes to exert its results and its minimal impact on hormone ranges.
Creatine HCL vs. Monohydrate: Professionals and Cons
Scientists developed creatine HCL to sidestep monohydrate’s commonest unwanted effects: water retention and weight acquire.
These unwanted effects sometimes have an effect on folks throughout a creatine “loading part,” the place you’re taking greater doses for the primary week of taking creatine monohydrate to accelerate its accumulation in your muscle mass.
Throughout this time, your physique may retain extra water than in the event you took smaller doses, doubtlessly inflicting short-term bloating and weight acquire.
Due to its chemical composition, HCL creatine is 38 instances extra soluble than monohydrate and doubtlessly extra “bioavailable.” As such, many consider taking HCL helps you keep away from antagonistic unwanted effects because you eat much less water and creatine than when supplementing with monohydrate.
Whereas these benefits sound promising, no proof confirms them in people, so you need to consider them as “potential” fairly than “confirmed” advantages till scientists verify them with high-quality analysis.
Another excuse to not get too jazzed about these potential “execs” is that loading creatine monohydrate is elective.
If you happen to’re frightened about experiencing unwanted effects, you possibly can merely skip the loading part and take 3-to-5 grams each day as an alternative. This method could imply it’s important to wait barely longer to expertise creatine’s performance-enhancing advantages, nevertheless it received’t influence its long-term effectiveness.
In different phrases, there’s no assure creatine HCL has any benefits over creatine monohydrate. And even when it does, you possibly can offset these benefits by taking much less monohydrate while you start supplementing.
A serious disadvantage of selecting HCL over monohydrate is the fee.
In a systematic review by the College of Colorado, researchers discovered that the majority types of creatine enhance efficiency to an analogous diploma, however creatine monohydrate is considerably extra reasonably priced. In accordance with their evaluation, the common price of a 5-gram serving of HCL is $1.10.
In the meantime, a 5-gram serving of monohydrate prices simply $0.29.
Creatine HCL vs. Monohydrate: Widespread Facet Results
As famous earlier, HCL creatine could barely scale back your danger of water retention, bloating, and short-term weight acquire in comparison with creatine monohydrate.
That mentioned, skipping the loading part when utilizing monohydrate may mitigate these unwanted effects.
Except for these minor and often short-lived drawbacks, creatine monohydrate and creatine HCL’s unwanted effects are minimal: each are usually secure, even when taking massive each day doses (30 grams per day) for a number of years.
Opposite to what some say, there’s no proof creatine causes zits, complications, or high blood pressure. Furthermore, it doesn’t disturb sleep, nearly definitely doesn’t cause hair loss, and offered you’ve got wholesome kidneys, it won’t harm kidney well being, both.
Creatine HCL vs. Creatine Monohydrate: Which Is Finest?
Analysis exhibits that creatine of any type improves your athletic efficiency in quite a few methods.
Nonetheless, no sort of creatine is as well-studied, secure, cost-effective, and dependable as creatine monohydrate.
Thus, monohydrate is the clear winner in a battle between creatine monohydrate vs. HCL.
For a pure supply of creatine monohydrate, attempt Legion’s micronized creatine monohydrate supplement, creatine gummies, or Recharge
FAQ #1: How a lot creatine HCL ought to I take?
The usual creatine HCL dosage is 3-to-5 grams. This dosage is identical as creatine monohydrate, regardless of some advertising claims suggesting which you can take much less creatine HCL as a result of it’s extra soluble.
FAQ #2: Does creatine make you greater?
Sure, each creatine HCL and monohydrate increase the quantity of water held in muscle cells, making your muscle mass seem greater.
It additionally positively impacts nitrogen balance and the expression of sure genes, which helps you acquire measurement by boosting muscle growth.
FAQ #3: When is the very best time to take creatine for muscle acquire?
There’s no “finest time to take creatine.”
Research exhibits it really works completely properly while you take it at any time of the day.
FAQ #4: What occurs while you cease taking creatine?
The creatine shops in your muscle mass will progressively deplete, inflicting your athletic efficiency to dip.
This doesn’t occur in a single day, although.
Supplied your muscle mass are totally saturated while you cease, you possibly can expect to hold onto roughly 80% of your saved creatine for as much as 2 weeks, and it’ll take round a month of not taking creatine earlier than your ranges return to “baseline.”
FAQ #5: Can you’re taking creatine earlier than mattress?
Sure, you possibly can take each creatine HCL and monohydrate earlier than mattress.
Creatine isn’t a stimulant, so taking it earlier than mattress received’t disturb your sleep.
Creatine could reduce whole and deep sleep period in animals.
Whereas lowering sleep period and high quality often harms psychological and bodily efficiency, other studies show that people taking creatine are mentally and bodily sharper, even when sleep-deprived.
Thus, it’s potential (although extremely speculative) that creatine may scale back your want for sleep and counteract the drawbacks of sleep deprivation.
Scientific References +
- Cooper, Robert, et al. “Creatine Supplementation with Specific View to Exercise/Sports Performance: An Update.” Journal of the International Society of Sports Nutrition, vol. 9, no. 1, 20 July 2012, www.ncbi.nlm.nih.gov/pmc/articles/PMC3407788/, https://doi.org/10.1186/1550-2783-9-33.
- Darrabie, Marcus D., et al. “AMPK and Substrate Availability Regulate Creatine Transport in Cultured Cardiomyocytes.” American Journal of Physiology. Endocrinology and Metabolism, vol. 300, no. 5, 1 May 2011, pp. E870-876, pubmed.ncbi.nlm.nih.gov/21364119/, https://doi.org/10.1152/ajpendo.00554.2010. Accessed 23 Dec. 2021.
- Guzun, R., et al. “Systems Bioenergetics of Creatine Kinase Networks: Physiological Roles of Creatine and Phosphocreatine in Regulation of Cardiac Cell Function.” Amino Acids, vol. 40, no. 5, 10 Mar. 2011, pp. 1333–1348, link.springer.com/article/10.1007%2Fs00726-011-0854-x, https://doi.org/10.1007/s00726-011-0854-x. Accessed 18 Nov. 2019.
- McCall, Wesley, and Adam M. Persky. “Pharmacokinetics of Creatine.” Sub-Cellular Biochemistry, vol. 46, 2007, pp. 261–273, pubmed.ncbi.nlm.nih.gov/18652081/. Accessed 18 Oct. 2023.
- Jd, Branch. “Effect of Creatine Supplementation on Body Composition and Performance: A Meta-Analysis.” International Journal of Sport Nutrition and Exercise Metabolism, 1 June 2003, pubmed.ncbi.nlm.nih.gov/12945830/.
- Camic, Clayton L, et al. “The Effects of Polyethylene Glycosylated Creatine Supplementation on Muscular Strength and Power.” Journal of Strength and Conditioning Research, vol. 24, no. 12, Dec. 2010, pp. 3343–3351, https://doi.org/10.1519/jsc.0b013e3181fc5c5c. Accessed 14 Apr. 2019.
- Eckerson, Joan M., et al. “Effect of Creatine Phosphate Supplementation on Anaerobic Working Capacity and Body Weight after Two and Six Days of Loading in Men and Women.” The Journal of Strength and Conditioning Research, vol. 19, no. 4, 2005, p. 756, https://doi.org/10.1519/r-16924.1.
- Anomasiri, Wilai, et al. “Low Dose Creatine Supplementation Enhances Sprint Phase of 400 Meters Swimming Performance.” Journal of the Medical Association of Thailand = Chotmaihet Thangphaet, vol. 87 Suppl 2, 1 Sept. 2004, pp. S228-232, pubmed.ncbi.nlm.nih.gov/16083193/. Accessed 7 July 2021.
- Safdar, Adeel, et al. “Global and Targeted Gene Expression and Protein Content in Skeletal Muscle of Young Men Following Short-Term Creatine Monohydrate Supplementation.” Physiological Genomics, vol. 32, no. 2, Jan. 2008, pp. 219–228, https://doi.org/10.1152/physiolgenomics.00157.2007.
- Tang, Fu-Chun, et al. “Contribution of Creatine to Protein Homeostasis in Athletes after Endurance and Sprint Running.” European Journal of Nutrition, vol. 53, no. 1, 8 Feb. 2013, pp. 61–71, https://doi.org/10.1007/s00394-013-0498-6. Accessed 19 Feb. 2019.
- Kreider, Richard B., et al. “International Society of Sports Nutrition Position Stand: Safety and Efficacy of Creatine Supplementation in Exercise, Sport, and Medicine.” Journal of the International Society of Sports Nutrition, vol. 14, no. 1, 13 June 2017, www.tandfonline.com/doi/full/10.1186/s12970-017-0173-z, https://doi.org/10.1186/s12970-017-0173-z.
- Stockbrugger, Barry A., and Robert G. Haennel. “Contributing Factors to Performance of a Medicine Ball Explosive Power Test: A Comparison between Jump and Nonjump Athletes.” Journal of Strength and Conditioning Research, vol. 17, no. 4, 1 Nov. 2003, pp. 768–774, pubmed.ncbi.nlm.nih.gov/14636108/, https://doi.org/10.1519/1533-4287(2003)0172.0.co;2.
- Gufford, Brandon T., et al. “Physicochemical Characterization of Creatine N-Methylguanidinium Salts.” Journal of Dietary Supplements, vol. 7, no. 3, 1 Sept. 2010, pp. 240–252, pubmed.ncbi.nlm.nih.gov/22432515/, https://doi.org/10.3109/19390211.2010.491507. Accessed 5 Nov. 2020.
- Gufford, Brandon T., et al. “PH-Dependent Stability of Creatine Ethyl Ester: Relevance to Oral Absorption.” Journal of Dietary Supplements, vol. 10, no. 3, 1 Sept. 2013, pp. 241–251, www.ncbi.nlm.nih.gov/pmc/articles/PMC4469200/, https://doi.org/10.3109/19390211.2013.822453. Accessed 10 Nov. 2021.
- Alraddadi, Eman, et al. “Absolute Oral Bioavailability of Creatine Monohydrate in Rats: Debunking a Myth.” Pharmaceutics, vol. 10, no. 1, 8 Mar. 2018, p. 31, https://doi.org/10.3390/pharmaceutics10010031. Accessed 12 May 2021.
- Kreider, Richard B. “Species-Specific Responses to Creatine Supplementation.” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, vol. 285, no. 4, Oct. 2003, pp. R725–R726, https://doi.org/10.1152/ajpregu.00375.2003. Accessed 26 Oct. 2020.
- França, Elias de, et al. “Creatine HCl and Creatine Monohydrate Improve Strength but Only Creatine HCl Induced Changes on Body Composition in Recreational Weightlifters.” Food and Nutrition Sciences, vol. 06, 2015, p. 1624, www.scirp.org/html/5-2701782_62283.htm#txtF9, https://doi.org/10.4236/fns.2015.617167.
- Fernandes, Caroline, et al. Comparison between Creatine Monohydrate and Creatine HCl on Body Composition and Performance of the Brazilian Olympic Team. 28 Mar. 2019.
- Tayebi, Milad , and Hamid Arazi. Is Creatine Hydrochloride Better than Creatine Monohydrate for the Improvement of Physical Performance and Hormonal Changes in Young Trained Men? Dec. 2019, https://doi.org/10.1016/j.scispo.2019.07.013.
- Bemben, Michael G, and Hugh S Lamont. “Creatine Supplementation and Exercise Performance.” Sports Medicine, vol. 35, no. 2, 2005, pp. 107–125, link.springer.com/article/10.2165/00007256-200535020-00002, https://doi.org/10.2165/00007256-200535020-00002.
- Kutz, Matthew R., and Michael J. Gunter. “Creatine Monohydrate Supplementation on Body Weight and Percent Body Fat.” The Journal of Strength and Conditioning Research, vol. 17, no. 4, 2003, p. 817, https://doi.org/10.1519/1533-4287(2003)017%3C0817:cmsobw%3E2.0.co;2. Accessed 1 Apr. 2019.
- Powers, Michael E., et al. “Creatine Supplementation Increases Total Body Water without Altering Fluid Distribution.” Journal of Athletic Training, vol. 38, no. 1, 2003, pp. 44–50, www.ncbi.nlm.nih.gov/pmc/articles/PMC155510/.
- Hultman, E., et al. “Muscle Creatine Loading in Men.” Journal of Applied Physiology, vol. 81, no. 1, July 1996, pp. 232–237, pubmed.ncbi.nlm.nih.gov/8828669/, https://doi.org/10.1152/jappl.1996.81.1.232.
- Fazio, Carly, et al. “Efficacy of Alternative Forms of Creatine Supplementation on Improving Performance and Body Composition in Healthy Subjects.” Journal of Strength and Conditioning Research, vol. Publish Ahead of Print, 11 Feb. 2021, https://doi.org/10.1519/jsc.0000000000003873. Accessed 10 Nov. 2021.
- Kreider, Richard B., et al. “International Society of Sports Nutrition Position Stand: Safety and Efficacy of Creatine Supplementation in Exercise, Sport, and Medicine.” Journal of the International Society of Sports Nutrition, vol. 14, no. 1, 13 June 2017, pubmed.ncbi.nlm.nih.gov/28615996/, https://doi.org/10.1186/s12970-017-0173-z.
- MIHIC, SASA, et al. “Acute Creatine Loading Increases Fat-Free Mass, but Does Not Affect Blood Pressure, Plasma Creatinine, or CK Activity in Men and Women.” Medicine & Science in Sports & Exercise, vol. 32, no. 2, Feb. 2000, p. 291, https://doi.org/10.1097/00005768-200002000-00007. Accessed 22 Apr. 2020.
- van der Merwe, Johann, et al. “Three Weeks of Creatine Monohydrate Supplementation Affects Dihydrotestosterone to Testosterone Ratio in College-Aged Rugby Players.” Clinical Journal of Sport Medicine, vol. 19, no. 5, Sept. 2009, pp. 399–404, https://doi.org/10.1097/jsm.0b013e3181b8b52f.
- Carvalho, Ana Paula Perillo Ferreira, et al. “Suplementação Com Creatina Associada Ao Treinamento Resistido Não Altera as Funções Renal E Hepática.” Revista Brasileira de Medicina Do Esporte, vol. 17, no. 4, Aug. 2011, pp. 237–241, https://doi.org/10.1590/s1517-86922011000400004. Accessed 4 Jan. 2022.
- Davani-Davari, Dorna, et al. “Potential Adverse Effects of Creatine Supplement on the Kidney in Athletes and Bodybuilders.” Iranian Journal of Kidney Diseases, vol. 12, no. 5, 1 Oct. 2018, pp. 253–260, pubmed.ncbi.nlm.nih.gov/30367015/.
- Parise, G., et al. “Effects of Acute Creatine Monohydrate Supplementation on Leucine Kinetics and Mixed-Muscle Protein Synthesis.” Journal of Applied Physiology, vol. 91, no. 3, 1 Sept. 2001, pp. 1041–1047, https://doi.org/10.1152/jappl.2001.91.3.1041.
- Candow, Darren G., et al. “Strategic Creatine Supplementation and Resistance Training in Healthy Older Adults.” Applied Physiology, Nutrition, and Metabolism, vol. 40, no. 7, July 2015, pp. 689–694, https://doi.org/10.1139/apnm-2014-0498.
- Safdar, Adeel, et al. “Global and Targeted Gene Expression and Protein Content in Skeletal Muscle of Young Men Following Short-Term Creatine Monohydrate Supplementation.” Physiological Genomics, vol. 32, no. 2, Jan. 2008, pp. 219–228, https://doi.org/10.1152/physiolgenomics.00157.2007.
- Dworak, Markus, et al. “Creatine Supplementation Reduces Sleep Need and Homeostatic Sleep Pressure in Rats.” Journal of Sleep Research, vol. 26, no. 3, 11 Apr. 2017, pp. 377–385, https://doi.org/10.1111/jsr.12523. Accessed 10 Dec. 2021.
- McMorris, T., et al. “Effect of Creatine Supplementation and Sleep Deprivation, with Mild Exercise, on Cognitive and Psychomotor Performance, Mood State, and Plasma Concentrations of Catecholamines and Cortisol.” Psychopharmacology, vol. 185, no. 1, 17 Jan. 2006, pp. 93–103, https://doi.org/10.1007/s00213-005-0269-z.
- McMorris, T., et al. “Creatine Supplementation, Sleep Deprivation, Cortisol, Melatonin and Behavior.” Physiology & Behavior, vol. 90, no. 1, Jan. 2007, pp. 21–28, https://doi.org/10.1016/j.physbeh.2006.08.024.
- Cook, Christian J, et al. “Skill Execution and Sleep Deprivation: Effects of Acute Caffeine or Creatine Supplementation – a Randomized Placebo-Controlled Trial.” Journal of the International Society of Sports Nutrition, vol. 8, no. 1, 16 Feb. 2011, https://doi.org/10.1186/1550-2783-8-2. Accessed 17 Feb. 2020.